Our Diamond Nitro Rolls and all of our Nitro Rolls are very safe. They are non-toxic, latex-free and would be safe for puppies to play, lay, and sleep on. Our Nitro Rolls have been used as flooring for doggy daycares, as flooring in puppy pens, and much more. They are very easy to clean and non-porous, making them very easy to disinfect. Since they are so thin, they are very easy to cut and can be cut to fit any area.